Ameliorated pancreatic beta cell dysfunction in type 2 diabetic patients treated with a sodium-glucose cotransporter 2 inhibitor ipragliflozin

作者：Takahara Mitsuyoshi; Shiraiwa Toshihiko; Matsuoka Taka aki^*; Katakami Naoto; Shimomura Iichiro

来源：Endocrine Journal, 2015, 62(1): 77-86.

DOI：10.1507/endocrj.ej14-0335

• Sodium-glucose cotransporter 2 (SGLT2) inhibitor
• Ipragliflozin
• beta cell function
• Disposition index
• Washout

It remains to be seen whether pancreatic beta cell dysfunction in type 2 diabetic patients can be ameliorated just by correcting hyperglycemia. The current pilot study investigated beta cell function after a four-week treatment with a sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin in Japanese patients with type 2 diabetes mellitus. Ten participants (age, 51 +/- 13 years; hemoglobin A1c levels, 9.4 +/- 1.0%) took 50 mg of ipragliflozin L-proline for four weeks and thereafter discontinued the agent for one week. A 75-g oral glucose tolerance test (OGTT) was performed at 0 (baseline), 4 (end of medication), and 5 weeks (end of washout). The 13 cell function was evaluated using the disposition index, which was calculated as the product of the Delta Ins(0-120)/Delta Glu(0-120) and the Matsuda index, where Delta Ins(0-120)/Delta Glu(0-120) represents the ratio of the incremental concentrations of insulin to those of glucose during the 0- to 120-min time period of the OGTT. The fasting glucose level was 182 +/- 34 mg/dL at 0 week, 137 +/- 20 mg/dL at 4 weeks (p < 0.001), and 154 +/- 31 mg/dL at 5 weeks (p = 0.001). Compared to baseline, the disposition index was significantly elevated not only at 4 weeks (p < 0.001) but also at 5 weeks (p = 0.008). In conclusion, the current pilot study showed that the beta cell function assessed by the OGTT-derived disposition index was significantly improved after a four-week treatment with ipragliflozin in Japanese patients with type 2 diabetes mellitus.

• 出版日期2015-1-20