科研之友
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摘要
The functional state of adenylyl cyclase signaling system (ACSS) and its regulation by the hormones and the inhibitor of adenylyl cyclase (AC), somatostatine (SST), in the brain and myocardium and by 5-nonyloxytryptamine (5-NOT) in the brain of rats of different ages (2- and 7-month-old) with experimental obesity and combination of obesity and type 2 diabetes mellitus (DM2), as well as the effect of the long-term treatment with intranasally administered insulin (II) on ACSS were studied. It was shown that the basal AC activity in obese and DM2 rats increases in the myocardium and, to a lesser extent, in the brain and decreases under the II treatment. The AC stimulating effect of forskolin decreases in the myocardium, but not in the brain of obese and DM2 rats. The II treatment recovers the AC stimulating effect of forskolin in 7-month-old animals, but has little effect in 5-month-old rats. In obesity as well as under the II treatment, the basal AC activity and its stimulation by forskolin change insignificantly. The AC inhibitory effects of 5-NOT and, particularly, SST are strongly attenuated in the investigated pathology, supposedly due to a reduction in the functional activity of G(i)-proteins. The treatment of obesity and its combination with DM2 recovers, completely or partially, the AC inhibitory effects of hormones, most of all in the brain. Since the ACSS dysfunctions are causal to metabolic syndrome and DM2, their elimination by the II treatment promises an effective approach to combat these pathologies and their CNS and cardiovascular complications.
- 出版日期2014-9
