An Efficient Approach to the Synthesis of Coumarin-Bearing 2,3-Dihydro-4(1H)-Quinazolinone Derivatives Using a Piperidine and Molecular Iodine Dual-Catalyst System

作者：Alizadeh, Abdolali^*; Ghanbaripour, Rashid; Zhu, Long-Guan

来源：Synlett, 2014, 25(11): 1596-1600.

DOI：10.1055/s-0033-1341202

• salicylaldehyde
• beta-keto ester
• isatoic anhydride
• ammonium acetate
• 2-alkyl-2-(2-oxo-2H-chromen-3-yl)-2,3-dihydro-4(1H)quinazolinone
• dual-catalyst system

An efficient dual-catalyst system of piperidine and molecular iodine has been developed for the synthesis of 2-alkyl-2(2-oxo-2H-chromen-3-yl)-2,3-dihydro-4(1H)quinazolinone derivatives by a four-component reaction of salicylaldehydes, beta-keto esters, ammonium acetate, and isatoic anhydride. Good yields, mild reaction conditions, and easy purification are attractive features of the present method.

• 出版日期2014-7
• 单位浙江大学