Modulation of stress related metabolism by dark chocolate Nutritional metabonomics as a tool to assess the metabolic responses to stress while classifying dietary responses in healthy individuals

作者：Collino Sebastian; Martin Francois Pierre J; Rezzi Serge; Kochhar Sunil^*

来源：Agro Food Industry Hi-Tech, 2010, 21(6): 28-30.

• Anxiety trait
• stress
• dark chocolate
• metabonomics
• mass spectrometry
• nuclear magnetic resonance spectroscopy
• nutrimetabonomics
• metabolic signatures

One of the important aspects of nutrition and health today is to determine the biochemical effects of diets and foods on individuals and to discern the mechanisms behind the biological activity of specific dietary components. Metabonomics, in particular, is able to generate multivariate information on a wide range of metabolites thus providing the possibility to measure subtle changes in biological processes as a result of different nutritional effects. In the present paper we have summarized recent applications in nutritional metabonomics; measuring the subjects' metabolic responses attributed to daily dark chocolate consumption, with emphasis on stress-related metabolism. Individuals experiencing higher everyday stress showed a distinct metabolic profile marked by differences in gut microbial, energy and hormonal metabolism. Within two weeks of consumption, dark chocolate had a positive impact on stress-associated metabolism shifting high stress metabolic features towards the levels found in less stress subjects. The observed reduced levels of stress-associated hormones and normalization of the stress-related metabolic differences suggest that daily consumption of dark chocolate significantly modulated the metabolism of study participants, with potential benefits in improving their metabolic reaction to stress.

• 出版日期2010-12