A Domino Approach for the Synthesis of alpha,beta-Epoxy Ketones from Carbonyl Compounds under Neat Conditions at Ambient Temperature

作者：Mahato Sachinta; Santra Sougata; De Aramita; Chatterjee Rana; Zyryanov Grigory V; Majee Adinath^*

来源：ChemistrySelect, 2018, 3(26): 7596-7601.

DOI：10.1002/slct.201801162

• aldehydes
• domino reaction
• alpha,beta-epoxy ketones
• ketones
• metal-free

An efficient method has been developed for the synthesis of alpha,beta-epoxy ketones from one pot reaction between aldehydes and ketones in presence of cesium carbonate and tert-butyl hydrogen peroxide (TBHP) under neat conditions. In this methodology we have used the one pot domino type reaction with aldehydes and ketones to get alpha,beta-epoxy ketones without presynthesized chalcone precursors. A library of alpha,beta-epoxy ketones having a variety of substituents has been synthesized. Clean reaction, mild reaction conditions, ease of product isolation/purification, easily accessible reactants, wide substrates scope and metal and solvent-free and environmental friendly reaction conditions are the notable advantages of the present method. The present methodology is applicable to gram scale synthesis.

• 出版日期2018-7-13