A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

作者:Cheng Xiamin; Li Lin; Uttamchandani Mahesh; Yao Shao Q*
来源:Chemical communications, 2014, 50(22): 2851-2853.
DOI:10.1039/c4cc00184b

摘要

A clickable and cell-permeable affinity-based probe (AfBP) was designed from staurosporine, by incorporating an electrophilic chloroacetamide warhead to facilitate in situ proteome labeling of a range of potential kinase targets.

  • 出版日期2014