Near-Infrared Fluorescence Imaging Probes for Intracellular Reactive Small Molecules

作者：Wang, Xu; Zhao, Qian; Sun, Juan; Lv, Jianzheng; Tang, Bo^*

来源：Progress in Chemistry, 2013, 25(2-3): 179-191.

• living cell
• reactive small molecules
• fluorescent probe
• near-infrared imaging

With the development of life sciences, a lot of energy has been put into the research on the pathological and physiological functions of intracellular reactive small molecules (RSMs). As an efficient technique suitable for visualization in vivo, confocal fluorescence imaging has been applied to the monitor of RSMs in biological samples. The near-infrared fluorescence imaging based on molecular probes and nano probes has shown attractive and extensive application prospect in virtue of low background, less cell photodamage, deeper penetration of tissue, and relatively high sensitivity. This review summarizes the recent progress on near-infrared fluorescent probes for cellular RSMs, of which reactive oxygen species, metal ions, H+, anion ions, and thiols are mainly introduced. Particularly, future study and prospect are envisioned.

• 出版日期2013-3-24
• 单位山东师范大学