Neuropharmacological effect of atomoxetine on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy

作者：Nagashima Masako; Monden Yukifumi^*; Dan Ippeita; Dan Haruka; Mizutani Tsutomu; Tsuzuki Daisuke; Kyutoku Yasushi; Gunji Yuji; Hirano Daisuke; Taniguchi Takamichi; Shimoizumi Hideo; Momoi Mariko Y; Yamagata Takanori; Watanabe Eiju

来源：Neurophotonics, 2014, 1(2): 025007.

DOI：10.1117/1.NPh.1.2.025007

• serotonin
• dorsolateral prefrontal cortex
• optical topography
• ventrolateral prefrontal cortex
• target detection
• autism spectrum disorder

The current study aimed to explore the neural substrate for atomoxetine effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 15 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after atomoxetine or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Fifteen age-, gender-, and intelligence quotient-matched normal controls without atomoxetine administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices. The right prefrontal and parietal activation was normalized after atomoxetine administration in ADHD children. This was in contrast to our previous study using a similar protocol showing methylphenidate-induced normalization of only the right prefrontal function. fNIRS allows the detection of differential neuropharmacological profiles of both substances in the attentional network: the neuropharmacological effects of atomoxetine to upregulate the noradrenergic system reflected in the right prefrontal and inferior parietal activations and those of methylphenidate to upregulate the dopamine system reflected in the prefrontal cortex activation.

• 出版日期2014-12