A quinone isolated from the nest of Vespa simillima and its growth-inhibitory effect on rat liver cancer cells

作者：Fujiwara Yurniko; Mangetsu Makoto; Yang Ping; Kofujita Hisayoshi; Suzuki Koichi; Ohfune Yasufumi; Shinada Tetsuro^*

来源：Biological & Pharmaceutical Bulletin, 2008, 31(4): 722-725.

DOI：10.1248/bpb.31.722

• social wasp
• nest material
• quinone
• cytotoxicity

A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8-seco-para-ferruginone. The synthetic quinone showed potent growth-inhibitory effects on rat hepatoma cells (IC50 value=1.9 mu m). Morphological analyses of dRLh84 cells using the synthetic compound were tested. Chromatin coagulation was induced by the synthetic compound at 31.6 mu m.

• 出版日期2008-4