Amine-Catalyzed Enantioselective 1,3-Dipolar Cycloadditions of Aldehydes to C, N-Cyclic Azomethine Imines

作者：Li, Wenjun; Jia, Qianfa; Du, Zhiyun; Zhang, Kun; Wang, Jian^*

来源：Chemistry - A European Journal, 2014, 20(16): 4559-4562.

DOI：10.1002/chem.201400333

• asymmetric synthesis
• cycloadditions
• enamines
• heterocycles
• tetrahydroisoquinoline

Amine-catalyzed enantioselective 1,3-dipolar cycloadditions of aldehydes to C,N-cyclic azomethine imines were developed. The reactions between diversely substituted C,N-cyclic azomethine imines and aldehydes proceeded smoothly in the presence of chiral prolinol silyl ether catalyst and gave the C-1-substituted tetrahydroisoquinolines in a highly stereoselective manner. These tetrahydroisoquinolines could be efficiently transformed to several other useful polycyclic frameworks.

• 出版日期2014-4-14
• 单位广东工业大学