Deregulation of miR-183 promotes melanoma development via lncRNA MALAT1 regulation and ITGB1 signal activation

作者：Sun, Yong; Cheng, Hongyu; Wang, Guangjun; Yu, Guojun; Zhang, Dawei; Wang, Yibing; Fan, Wei^*; Yang, Weixi^*

来源：Oncotarget, 2017, 8(2): 3509-3518.

DOI：10.18632/oncotarget.13862

• miR-183
• MALAT1
• ITGB1
• melanoma
• competitive endogenous RNA

Dysregulation of miR-183 has been recently elucidated in several carcinomas. However, the expression patterns and mechanisms of miR-183 involved in malignant melanoma remain unidentified. Here, we found down-regulation of miR-183 in melanoma tissues and cells. Decreased level of miR-183 was relevant to poor overall survival, while miR-183 up-regulation resulted in a marked suppression of cell growth in vitro and in vivo. We further found that the expression and function of miR-183 were suppressed by MALAT1. Integrin beta 1 (ITGB1) was then speculated and confirmed as a direct target of miR-183. We also illustrated that MALAT1 may function as a sponge competitive endogenous RNA (ceRNA) for miR-183, and thus regulate the molecular expression of ITGB1. Collectively, we found a new signaling pathway promoting melanoma development by MALAT1-miR-183-ITGB1 axis, which may be clinically valuable as new targets for malignant melanoma therapy.

• 出版日期2017-1-10
• 单位南京医科大学