A case of carcinomatous meningitis despite prophylactic cranial irradiation in small cell lung cancer during treatment with amrubicin

作者：Oguri Tetsuya^*; Uemura Takehiro; Kunii Eiji; Ozasa Hiroaki; Ohkubo Hirotsugu; Miyazaki Mikinori; Maeno Ken; Sato Shigeki

来源：Oncology Letters, 2012, 4(2): 305-306.

DOI：10.3892/ol.2012.725

• small cell lung cancer
• prophylactic cranial irradiation
• leptomeningeal carcinomatosis
• amrubicin

A 47-year-old man was diagnosed with limited-disease small cell lung cancer. Treatment was initiated with concurrent chemotherapy and radiotherapy. A partial response was achieved, and prophylactic cranial irradiation (PCI) was administered. Local recurrence was identified on follow-up and treated with amrubicin (AMR). After two courses of AMR, a state of stable disease was achieved and AMR treatment was continued. After the third course of AMR, the patient was urgently hospitalized suffering from a headache and disturbance of consciousness, and a diagnosis of carcinomatous meningitis was made. This case report concerns a case of carcinomatous meningitis despite PCI during treatment with AMR.

• 出版日期2012-8