Neuropsychological and psychiatric outcomes in poorly controlled idiopathic generalized epilepsy

作者：Sarkis Rani A^*; Pietras Alison Camille; Cheung Angeles; Baslet Gaston; Dworetzky Barbara

来源：Epilepsy and Behavior, 2013, 28(3): 370-373.

DOI：10.1016/j.yebeh.2013.05.020

• Idiopathic generalized epilepsy
• Temporal lobe epilepsy
• Cognition
• Neuropsychology
• Depression
• Outcomes
• Psychiatry
• Medically
• refractory

The neuropsychological and psychiatric outcomes of patients with poorly controlled idiopathic generalized epilepsy (IGE) have not been well characterized. The current study aimed to compare these outcomes to a group of patients with medically refractory temporal lobe epilepsy (TLE). A retrospective review of patients admitted to the epilepsy monitoring unit identified 19 patients with IGE and 23 patients with TLE who underwent neuropsychological and psychiatric evaluations. Patients with IGE required a longer time to complete the Trail Making Tests and had lower performance IQ compared to patients with TLE. Despite a higher burden of convulsions, patients with IGE had lower depression scores on the Beck Depression Inventory II (BDI-II) than patients with TLE. In the group with IGE, the BDI-II scores were inversely correlated with epilepsy duration. These findings indicate that patients with ICE have lower performance IQ impaired performance on tests of executive functioning, and lower depression scores compared to patients with TLE, implicating different pathophysiological processes.

• 出版日期2013-9