Acute toxicity, antiedematogenic activity, and chemical constituents of Palicourea rigida Kunth

作者:Alves Vanessa G; da Rosa Elisa A; de Arruda Laura L M; Rocha Bruno A; Bersani Amado Ciomar A; Santin Silvana M O; Pomini Armando M; da Silva Cleuza C*
来源:Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2016, 71(3-4): 39-43.
DOI:10.1515/znc-2015-0036

摘要

The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin (5). These compounds were identified using NMR H-1 and C-13 and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the n-hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.

  • 出版日期2016-3

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