A novel synthesis of 5-substituted isoxazoles from propargylic amines and N-hydroxyphthalimide

作者：Zhang, Yicheng; Chen, Wei^*; Jia, Xueshun^*

来源：Tetrahedron Letters, 2018, 59(22): 2181-2183.

DOI：10.1016/j.tetlet.2018.04.062

• Isoxazole
• N-hydroxyphthalimide
• N-propargylamine

A mild and efficient method for the synthesis of 5-substituted isoxazoles through cyclization of propar- gylic amines with N-hydroxyphthalimide (NHPI) under metal-free conditions was developed.

• 出版日期2018-5-30
• 单位上海大学; 淮北师范大学