Antifouling properties of poly(dimethylsiloxane) surfaces modified with quaternized poly(dimethylaminoethyl methacrylate)

作者：Tu, Qin; Wang, Jian-Chun; Liu, Rui; He, Juan; Zhang, Yanrong; Shen, Shaofei; Xu, Juan; Liu, Jianjun; Yuan, Mao-Sen; Wang, Jinyi^*

来源：Colloids and Surfaces B: Biointerfaces , 2013, 102: 361-370.

DOI：10.1016/j.colsurfb.2012.08.033

• Poly(dimethylsiloxane)
• Surface modification
• SI-ATRP
• Cationic polymer
• Antifouling

A quaternized poly(dimethylaminoethyl methacrylate)-grafted poly(dimethylsiloxane) (PDMS) surface (PDMS-QPDMAEMA) was successfully prepared in this study via solution-phase oxidation reaction and surface-initiated atom transfer radical polymerization (SI-ATRP) using dimethylaminoethyl methacrylate (DMAEMA) as initial monomer. PDMS substrates were first oxidized in H2SO4/H2O2 solution to transform the Si-CH3 groups on their surfaces into Si OH groups. Subsequently, a surface initiator for ATRP was immobilized onto the PDMS surface, and DMAEMA was then grafted onto the PDMS surface via copper-mediated ATRP. Finally, the tertiary amino groups of PolyDMAEMA (PDMAEMA) were quaternized by ethyl bromide to provide a cationic polymer brush-modified PDMS surface. Various characterization techniques, including contact angle measurements, attenuated total reflection infrared spectroscopy. and X-ray photoelectron spectroscopy, were used to ascertain the successful grafting of the quaternized PDMAEMA brush onto the PDMS surface. Furthermore, the wettability and stability of the PDMS-QPDMAEMA surface were examined by contact angle measurements. Antifouling properties were investigated via protein adsorption, as well as bacterial and cell adhesion studies. The results suggest that the PDMS-QPDMAEMA surface exhibited durable wettability and stability, as well as significant antifouling properties, compared with the native PDMS and PDMS-PDMAEMA surfaces. In addition, our results present possible uses for the PDMS-QPDMAEMA surface as adhesion barriers and antifouling or functional surfaces in PDMS microfluidics-based biomedical applications.

• 出版日期2013-2-1
• 单位西北农林科技大学