Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain

作者：Nakano Yousuke; Furube Eriko; Morita Shoko; Wanaka Akio; Nakashima Toshihiro; Miyata Seiji^*

来源：Journal of Neuroimmunology, 2015, 278: 144-158.

DOI：10.1016/j.jneuroim.2014.12.013

• Inflammation
• Astrocyte
• Microglia
• Brain
• Fever

The sensory circumventricular organs (CVOs) comprise the organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), and area postrema (AP) and lack the blood-brain barrier. The expression of Toll-like receptor 4 (TLR4) was seen at astrocytes throughout the sensory CVOs and at microglia in the AP and solitary nucleus around the central canal. The peripheral and central administration of lipopolysaccharide induced a similar pattern of nuclear translocation of STAB. A microglia inhibitor minocycline largely suppressed lipopolysaccharide-induced astrocytic nuclear translocation of STAT3 in the OVLT and AP, but its effect was less in the SFO.

• 出版日期2015-1-15