Association of Vascular Endothelial Growth Factor -2578C/A Gene Polymorphism in Chinese Patients with Colon Cancer

作者：Zhang, Lin; Zhang, Guohu; Wang, Peihong; Gong, Jiaqing; Cao, Yongkuan; Tang, Lijun^*

来源：Genetic Testing and Molecular Biomarkers, 2011, 15(3): 117-121.

DOI：10.1089/gtmb.2010.0166

• MICROVESSEL DENSITY
• FACTOR VEGF
• BREAST-CANCER
• EXPRESSION
• PROGNOSIS
• ANGIOGENESIS
• SUSCEPTIBILITY
• PERMEABILITY
• METASTASIS
• STATISTICS

The vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in the process of angiogenesis, a crucial phase in tumor growth and metastasis. We carried out a case-control study to evaluate whether VEGF -2578C/A gene polymorphism modulates the risk of developing colon cancer. A total of 110 colon cancer patients and 110 cancer-free healthy people were recruited in the Chinese population. Genomic DNA was isolated from peripheral blood, and gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Colon cancer patients had a significantly higher frequency of VEGF -2578AA genotype (odds ratio = 2.49; 95% confidence interval = 1.04, 6.01; p = 0.04) than controls. Patients with left colon cancer had a significantly higher frequency of VEGF -2578AA genotype (odds ratio = 2.31; 95% confidence interval = 1.03, 5.18; p = 0.04) than those with right colon cancer. When stratified by tumor size, growth pattern, differentiation, and stage of colon cancer, no statistically significant results were observed. This study suggested that VEGF -2578AA genotype was associated with a higher risk of colon cancer in Chinese population. Further studies are needed to understand the mechanism of VEGF gene polymorphisms in the development and progression of colon cancer.

• 出版日期2011-3
• 单位中国人民解放军成都军区总医院