Naproxen drug delivery using periodic mesoporous silica SBA-15

作者：Halamova Dasa^*; Badanicova Maria; Zelenak Vladimir; Gondova Tat'ana; Vainio Ulla

来源：Applied Surface Science, 2010, 256(22): 6489-6494.

DOI：10.1016/j.apsusc.2010.04.044

• Mesoporous silica
• Naproxen
• Controlled release
• Drug delivery

In this paper, we present the release of naproxen from hexagonal periodic mesoporous silica SBA-15, which serves as a drug delivery system. Naproxen, the well-known nonsteroidal anti-inflammatory drug (NSAID), was loaded into the pores of SBA-15 silica modified with aminopropyl groups. The physicochemical properties of the modified sample (A-SBA-15/napro) were compared with the unmodified SBA-15 mesoporous silica loaded with the drug (SBA-15/napro). The kinetic of the naproxen release into the physiological solution was studied. The released amount of naproxen represented 90.7% from the unmodified SBA-15 in 72 h, while from the sample A-SBA-15/napro the released amount represented about 80.9%. The prepared materials were characterized by nitrogen adsorption/desorption, Small angle X-ray scattering (SAXS), Fourier-transform infrared spectroscopy (FT-IR) and the thermoanalytical methods (TG/DTA). Thin layer chromatography (TLC) was used for quantitative determination of the released naproxen.

• 出版日期2010-9-1