NKG2D Expression on HIV-Specific CD8(+) T cells Is Reduced in Viremic HIV-1-Infected Patients but Maintained in HIV Controllers

作者：Lecuroux Camille; Saez Cirion Asier; Noel Nicolas; Ben Lamine Lilia; Girault Isabelle; Caillat Zucman Sophie; Scott Algara Daniel; Venet Alain; Lambotte Olivier^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2013, 62(1): 17-20.

DOI：10.1097/QAI.0b013e318274579f

• NKG2D
• HIV-specific CD8(+) T lymphocytes
• inflammation
• HIV controllers

NKG2D mediates an important costimulatory pathway in CD8(+) T cells. In HIV infection, the authors found that NKG2D expression on both total CD8(+) and HIV-specific CD8(+) T cells was significantly lower in viremic patients than in HIV controllers. Antiretroviral therapy partially restored NKG2D expression on HIV-specific CD8(+) T cells. The authors observed a negative correlation between the respective expression levels of CD38 and NKG2D on total CD8(+) and HIV-specific CD8(+) T cells. The maintenance of NKG2D expression on CD8(+) T cells in HIV controllers may contribute to better cell function.

• 出版日期2013-1-1