科研之友
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摘要
Through the use of chemical synthesis and high throughput screening, we discovered a sulfonamide hydroxamic acid inhibitor for the botulinum neurotoxin serotype A light chain. A structure activity relationship study of the parent inhibitor resulted in the synthesis of a new inhibitor with an IC50 of 0.95 +/- 0.60 mu M for the BoNT/A LC.
- 出版日期2014-6
