New information on high risk breast screening

作者：Riedl C C; Ponhold L; Gruber R; Pinker K; Helbich T H^*

来源：Radiologe, 2010, 50(11): 955-+.

DOI：10.1007/s00117-010-2011-z

• Breast cancer
• Screening
• Magnetic resonance imaging
• BRCA genes
• High risk factors

Women with an elevated risk for breast cancer require intensified screening beginning at an early age. Such high risk screening differs considerably from screening in the general population. After an expert has evaluated the exact risk a breast MRI examination should be offered at least once a year and beginning latest at the age of 30 depending on the patients risk category. Complementary mammograms should not be performed before the age of 35. An additional ultrasound examination is no longer recommended. To ensure a high sensitivity and specificity high risk screening should be performed only at a nationally or regionally approved and audited service. Adequate knowledge about the phenotypical characteristics of familial breast cancer is essential. Besides the common malignant phenotypes, benign morphologies (round or oval shape and smooth margins) as well as a low prevalence of calcifications have been described. Using MRI benign contrast media kinetics as well as non-solid lesions with focal, regional and segmental enhancement can often be visualized.

• 出版日期2010-11