Adhesion and Proliferation of Osteoblast on the Amidation Surface of Polylactide Film

作者：Tian Ye; Wang Ying Jun; Zhou Chang Ren^*; Zeng Qing Hui; Tan Guo Xing

来源：Chemical Journal of Chinese Universities, 2009, 30(12): 2491-2495.

• Polylactide
• Amidation surface
• Graft polymerization
• Adhesion and proliferation

Acrylic amide(AAm) was polymerized onto polylactide(PLA) film via UV irradiation to achieve amidation surface, furthermore the adhesion and proliferation of osteoblast on this surface was investigated. The results show that the hydrophilicity of PLA film is improved by introduction amido: the contact angle decreases from 78 degrees to 56 degrees and the free energy increases from 42.7 mJ/m(2) to 51.4 mJ/m(2). Compared with the control, osteoblast spread out more filopodia after 3 d incubation on amidation surface, and it entered cell division phase more quickly, which indicated that the surface amidation could promote the cell's adhesion and proliferation on the PLA film.

• 出版日期2009-12-10
• 单位华南理工大学; 广东工业大学; 暨南大学