Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

作者：Cerella Claudia; Dicato Mario; Diederich Marc^*

来源：Mitochondrion, 2013, 13(3): 225-234.

DOI：10.1016/j.mito.2012.06.003

• Cardiac glycosides
• Sodium/potassium-ATPase
• Apoptosis
• Autophagy
• Cell cycle
• Mcl-1

Cardiac glycosides (CGs) are compounds used for the treatment of cardiac failure which also display strong anti-cancer activity inducing impairment of cell proliferation or activation of cell death whether by apoptosis or autophagy. Despite the fact that the sodium/potassium (Na+/K+)-ATPase is a well-known target of CGs, its involvement in the anti-cancer effect of these compounds remains to be validated. Importantly, related intra-cellular sensor(s)/transducer(s) needs further characterization. We will discuss here key mechanisms activated by CGs including their ability to modulate the cell cycle and to regulate the expression of anti-apoptotic Bcl-2 family members, two so far marginally investigated events.

• 出版日期2013-5