Mechanical tissue optical clearing technique increases imaging resolution and contrast through Ex vivo porcine skin (vol 43, pg 814, 2011)

作者：Izquierdo Roman Alondra; Vogt William C; Hyacinth Leeanna; Rylander Christopher G^*

来源：Lasers in Surgery and Medicine, 2011, 43(10): 998-1007.

DOI：10.1002/lsm.21158

• compression
• USAF target
• indentation
• load
• glycerol
• thickness
• brightfield

Background and Objectives Mechanical tissue optical clearing permits light delivery deeper into turbid tissue, which may improve current optical diagnostics and laser-based therapeutic techniques. We investigated the effects of localized compression on brightfield imaging through ex vivo porcine skin by evaluating resolution and contrast of a target positioned beneath native, mechanically compressed, or chemically cleared specimens. We also evaluated the effects of indentation on dynamic tissue thickness and light transmission.

• 出版日期2011-12
• 单位美国弗吉尼亚理工大学(Virginia Tech)