A newly synthesized, potent tyrosinase inhibitor: 5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol

作者：Choi Jehun; Bae Sung Jin; Ha Young Mi; No Jae Kyung; Lee Eun Kyeong; Lee Jun Sik; Song Suhee; Lee Hyojin; Suh Hongsuk; Yu Byung Pal; Chung Hae Young^*

来源：Bioorganic & Medicinal Chemistry Letters, 2010, 20(16): 4882-4884.

DOI：10.1016/j.bmcl.2010.06.087

• 5-(6-Hydroxy-2-naphthyl)-1,2,3-benzenetriol (5HNB)
• Tyrosinase inhibitor
• Melanin

In searching for new agents with a depigmenting effect, we synthesized a derivative of resveratrol, 5-(6-hydroxy-2-naphthyl)-1,2,3-benzenetriol ( 5HNB) with a potent tyrosinase inhibitory activity. 5HNB inhibited mushroom tyrosinase with an IC(50) value of 2.95 mu M, which is more potent than the well-known anti-tyrosinase activity of kojic acid (IC(50) = 38.24). The results of the enzymatic inhibition kinetics by Lineweaver-Burk analysis indicated 5HNB inhibits tyrosinase non-competitively when L-tyrosine was used as the substrate. Based on the strong inhibitory action of 5HNB, it is expected that 5HNB can suppress melanin production in which tyrosinase plays the essential role. Our expectation was confirmed by the experimentations with B16 melanoma cells in which 5HNB inhibited melanin production. We propose that 5HNB might have skin-whitening effects as well as therapeutic potential for treating skin pigmentation disorders.

• 出版日期2010-8-15