Detection of prenatal exposure to several classes of environmental toxicants and their metabolites by gas chromatography-mass spectrometry in maternal and umbilical cord blood

作者：Corrion ML; Ostrea EM^*; Bielawski DM; Posecion NC; Seagraves JJ

来源：Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2005, 822(1-2): 221-229.

DOI：10.1016/j.jchromb.2005.06.007

• pyrethroids
• pesticides
• whole blood
• parental pesticide exposure
• cord blood
• GC-MS
• environmental pollutants
• carbarnates
• organophosphates
• herbicide

We developed a sensitive method to detect several classes of pesticides and their metabolites in maternal and cord whole blood using electron-impact gas chromatography-mass spectrometry (GC-MS). The method can detect parent and metabolite compounds at levels of < 0.10 and 0.20 mu g/mL, respectively, with high accuracy and recovery. Analysis of blood from mother-infant dyads from an area of high pesticide use in the Philippines showed detectable levels of propoxur, 3-phenoxybenzoic acid (3-PBA), and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) in maternal and umbilical cord blood. GC-MS analysis of several classes of parent pesticides and their metabolites in maternal and cord blood provides a sensitive and specific method to detect pesticide exposure during pregnancy.

• 出版日期2005-8-5