Mechanisms of interaction between protozoan parasites and HIV

作者：Andreani Guadalupe; Lodge Robert; Richard Dave; Tremblay Michel J^*

来源：Current Opinion in HIV and AIDS, 2012, 7(3): 276-282.

DOI：10.1097/COH.0b013e32835211e9

• Chagas disease
• HIV
• leishmaniasis
• malaria
• protozoan parasite

Purpose of review %26lt;br%26gt;This review summarizes the current knowledge on human immunodeficiency virus type 1 (hereinafter called HIV)/protozoan co-infections in the case of three important, although neglected, tropical diseases: malaria, trypanosomiasis (Chagas disease) and leishmaniasis. The HIV pandemic has modified the immunopathogenic, epidemiological and therapeutic aspects of these human diseases. %26lt;br%26gt;Recent findings %26lt;br%26gt;In-vitro data suggests that HIV favors Leishmania infection, whereas different parasites have contrasting effects on HIV. However, many of the previous models are a limited representation of the complex interactions within the host; this situation is particularly the case when microbial products are used in place of live parasites. %26lt;br%26gt;Summary %26lt;br%26gt;In the host, protozoan parasites generally enhance HIV replication and accelerate AIDS progression. HIV alters parasite pathogenesis, often worsening disease outcome. These aspects bring significant complications for the treatment of co-infected individuals.

• 出版日期2012-5