Aspiperidine oxide, a piperidine N-oxide from the filamentous fungus Aspergillus indologenus

作者：Petersen Lene M; Kildgaard Sara; Jaspars Marcel; Larsen Thomas O^*

来源：Tetrahedron Letters, 2015, 56(14): 1847-1850.

DOI：10.1016/j.tetlet.2015.02.082

• Aspergillus indologenus
• Biosynthesis
• N-Oxide
• Dipeptide

A novel secondary metabolite, aspiperidine oxide, was isolated from the filamentous fungus, Aspergillus indologenus. The structure of aspiperidine oxide was determined from extensive 1D and 2D NMR spectroscopic analysis supported by high-resolution mass spectrometry. The structure revealed a rare piperidine N-oxide, not observed in filamentous fungi before. A biosynthetic pathway towards aspiperidine oxide is proposed, based on tentative identification of intermediates from UHPLC-DAD-HRMS data.

• 出版日期2015-4-1