Assessment of Microbiological Status after Successful Completion of Intermittent Revised National Tuberculosis Control Programme Directly Observed Treatment, Short Course Regimen for Microbiologically Confirmed Pulmonary Tuberculosis Cases: While New Daily Regimen Going to be Implemented in India

作者：Ghosh, Roumi^*; Roy, Sudipta; Rashid, Md. Khalid

来源：Indian Journal of Medical Microbiology, 2018, 36(2): 251-256.

DOI：10.4103/ijmm.IJMM_18_65

• Daily regimen
• Directly Observed Treatment
• Short Course
• intermittent therapy
• relapse
• tuberculosis

Purpose: The Revised National Tuberculosis Control Programme (RNTCP) is now introducing daily fixed-dose regimen instead of Directly Observed Treatment, Short Course (DOTS) regimen for treatment of drug-sensitive tuberculosis (TB) in India. It would be beneficial to understand the drawbacks, barriers and advantages of the existing system for better implementation of new policy. Our study was aimed to evaluate the current microbiological status of new microbiologically confirmed pulmonary TB patients who have successfully completed intermittent DOTS regimen within last 2 years and also to find the economic barriers faced by beneficiaries to avail DOTS treatment. Materials and Methods: We included patients who had completed CAT 1 DOTS regimen within the last 2 years. The patients were interviewed. Sputum sample was collected for microscopy and cartridge-based nucleic acid amplification test. Results: All patients were adhered to intermittent DOTS therapy, and sputum conversion rate was 83%. Minor gastrointestinal side effects were experienced by 60% of cases and 87% consumed drugs under supervision. On microbiological examination, 10% of the study population was found to be positive for TB and they all were rifampicin sensitive. Those who had completed treatment within 1 year with no clinical symptoms re-appeared after treatment. Conclusion: Till date, RNTCP does not follow up the patients for any period of time after successful completion of treatment. Through the present study, we could find relapse cases in 10% of the previously treated non-symptomatic patients. These unnoticed relapse cases have potential to spread TB and increase disease burden of country. Thus, we can conclude that RNTCP has to follow up the patients after successful treatment to determine whether they relapse. It is needed for the success of programme and control of the disease in the country.

• 出版日期2018-6
• 单位河北医科大学