Ampakine CX1942 attenuates opioid-induced respiratory depression and corrects the hypoxaemic effects of etorphine in immobilized goats (Capra hircus)

作者：Haw Anna J; Meyer Leith C R; Greer John J; Fuller Andrea

来源：Veterinary Anaesthesia and Analgesia, 2016, 43(5): 528-538.

DOI：10.1111/vaa.12358

• CX1942
• doxapram
• hyperventilation
• wildlife

ObjectivesTo determine whether CX1942 reverses respiratory depression in etorphine-immobilized goats, and to compare its effects with those of doxapram hydrochloride.
Study designA prospective, crossover experimental trial conducted at 1753m.a.s.l.
AnimalsEight adult female Boer goats (Capra hircus) with a meanstandard deviation mass of 27.11.6kg.
MethodsFollowing immobilization with 0.1mgkg(-1) etorphine, goats received one of doxapram, CX1942 or sterile water intravenously, in random order in three trials. Respiratory rate, ventilation and tidal volume were measured continuously. Arterial blood samples for the determination of PaO2, PaCO2, pH and SaO(2) were taken 2minutes before and then at 5minute intervals after drug administration for 25minutes.
ResultsDoxapram corrected etorphine-induced respiratory depression but also led to arousal and hyperventilation at 2minutes after its administration, as indicated by the low PaCO2 (27.8 +/- 4.5mmHg) and ventilation of 5.32 +/- 5.24Lminute(-1) above pre-immobilization values. CX1942 improved respiratory parameters and corrected etorphine's hypoxaemic effects more gradually than did doxapram, with a more sustained improvement in PaO2 and SaO(2) in comparison with the control trial.
ConclusionsCX1942 attenuated opioid-induced respiratory depression and corrected the hypoxaemic effects of etorphine in immobilized goats.
Clinical relevanceAmpakines potentially offer advantages over doxapram, a conventional treatment, in reversing etorphine-induced respiratory depression without causing unwanted side effects, particularly arousal, in immobilized animals.

• 出版日期2016-9