Actividad de la proteinasa en cepas de Candida albicans aisladas de la cavidad oral de pacientes inmunodeprimidos, con candidiasis oral y sujetos sanos

作者：Hernandez Solis Sandra E^*; Rueda Gordillo Florencio; Rojas Herrera Rafael A

来源：Revista Iberoamericana de Micologia, 2014, 31(2): 137-140.

DOI：10.1016/j.riam.2013.09.003

• Candida albicans
• Proteinase
• Virulence factors
• Healthy carriers
• Diabetes Human immunodeficiency virus
• Cancer Oral candidiasis

Background: Candida albicans has a variety of virulence factors, including secreted aspartyl proteases, which are determinant factors in the pathogenesis of this yeast in immunocompromised patients.
Aims: Proteinase activity was identified in C. albicans strains isolated from the oral cavity of immunocompromised patients with cancer, diabetes and HIV+, with oral candidiasis and in healthy subjects.
Methods: Two hundred and fifty C. albicans strains were analyzed, distributed in 5 different groups: patients with cancer, diabetes, HIV+, with oral candidiasis and healthy subjects.
Results: Proteolytic activity was identified in 46% of the strains from cancer patients, 54% from HIV+ patients, 60% from diabetics, 70% from oral candidiasis patients, and 42% from healthy subjects. Activity was higher in strains from immunocompromised and oral candidiasis patients than in healthy subjects. Differences were observed between the candidiasis-healthy, candidiasis-HIV+, and diabetic-healthy groups. No differences were observed between the oral candidiasis, diabetes and cancer patients, between the diabetes and HIV+ patients, or between the cancer patients, HIV+ patients and healthy subjects.
Conclusions: The present results suggest that although secreted aspartyl proteases are important in the pathogenesis of C albi cans, their activity depends on host conditions.

• 出版日期2014-4-30