Non-contacting photoacoustic tomography in biological samples

作者：Wang, Cheng^*; Cai, Gan; Dong, Xiaona; Yang, Jing; Weng, Xiaofu; Wei, Xunbin

来源：Journal of Biomedical Engineering, 2017, 34(3): 439-444.

DOI：10.7507/1001-5515.201603045

• Biological tissues
• Biomedical optics
• Interferometric techniques
• Laser heterodyne interferometry
• Multi-layered structure
• Non-contact
• Photoacoustic tomography
• Reconstruction algorithms

In photoacoustic imaging the ultrasonic signals are usually detected by contacting transducers. For some applications, contact with the tissue should be avoided, e.g. in those of brain functional imaging. As alternatives to contacting transducers interferometric techniques can be used to acquire photoacoustic signals remotely. Here, a system for non-contact photoacoustic tomography imaging (NCPAT) has been established. This approach enables NCPAT not to exceed laser exposure safety limits. The stimulated source of NCPAT utilized a laser with center wavelength of 532 nm and output intensity of 17.5 mJ/cm2, and a laser heterodyne interferometry was used to receive the photoacoustic signals. The NCPAT was used to implement on a rotational imaging geometry for photoacoustic tomography with a real-tissue phantom. The photoacoustic imaging was obtained by applying a reconstruction algorithm to the data acquired for NCPAT. Experiments results showed that the NCPAT system with detection 15 dB bandwidth of 2.25 MHz could resolve spherical optical inclusions with dimension of 500 μm and multi-layered structure with optical contrast in strongly scattering medium. The method could expand the scope of photoacoustic and ultrasonic technology to in-vivo biomedical applications where contact is impractical.

• 出版日期2017
• 单位上海交通大学