Association Between Serum Triglycerides and Cerebral Amyloidosis in Cognitively Normal Elderly

作者：Choi Hyo Jung; Byun Min Soo; Yi Dahyun; Choe Young Min; Sohn Bo Kyung; Baek Hye Won; Lee Jun Ho; Kim Hyun Jung; Han Ji Young; Yoon Eun Jin; Kim Yu Kyeong; Woo Jong Inn; Lee Dong Young^*

来源：American Journal of Geriatric Psychiatry, 2016, 24(8): 604-612.

DOI：10.1016/j.jagp.2016.03.001

• Alzheimer disease
• brain amyloid
• triglycerides
• lipid
• PET

Objectives: Although many preclinical studies have suggested the possible linkage between dyslipidemia and cerebral amyloid deposition, the association between serum lipid measures and cerebral amyloid-beta (A beta) deposition in human brain is still poorly known. We aimed to investigate the association in cognitively normal (CN) elderly individuals. Design: Cross-sectional study. Setting: University hospital dementia clinic. Participants: 59 CN elderly. Measurements: The study measures included comprehensive clinical and neuropsychological assessment based on the CERAD protocol, magnetic resonance imaging and C-11-labelled Pittsburgh Compound B positron emission tomography scans, and quantification for serum lipid biomarkers. Results: Multiple linear regression analyses showed that a higher serum triglycerides level was associated with heavier global cerebral A beta deposition even after controlling age, sex, and apolipoprotein E epsilon 4 genotype. Serum apolipoprotein B also showed significant positive association with global cerebral A beta deposition, but the significance disappeared after controlling serum triglycerides level. No association was found between other lipid measures and global cerebral A beta deposition. Conclusions: The findings suggest that serum triglycerides are closely associated with cerebral amyloidosis, although population-based prospective studies are needed to provide further evidence of the causative effect of triglycerides on cerebral amyloidosis.

• 出版日期2016-8