An improved synthesis of sitophilure

作者:Lu Cuifen*; Nie Junqi; Yang Guichun; Chen Zuxing
来源:Canadian Journal of Chemistry, 2009, 87(1): 30-32.
DOI:10.1139/V08-032

摘要

The asymmetric synthesis of sitophilure was carried out in 8 steps, with 42% overall yield and 97% enantiomeric excess from propionaldehyde. The synthesis relied on an approach employing an asymmetric acylthiazolidinethione propionate aldol reaction to establish two stereogenic centers.