Drug-induced liver injury as predominant cause of acute liver failure in a monocenter study

作者：Bechmann L P; Manka P; Best J; Saner F H; Paul A; Canbay A^*; Gerken G

来源：Deutsche Medizinische Wochenschrift, 2014, 139(17): 878-882.

DOI：10.1055/s-0034-1369932

• acute liver failure
• liver transplantation
• DILI

Background and aim: Clinical course and mortality of acute liver failure (ALF) are determined by its causes. Traditionally, fulminant hepatitis B infection (HBV) was thought to be the predominant etiology of ALF in Germany. However, recent studies, conducted in American and European cohorts pointed to drug-induced liver injury (DILI) as the major cause. Aim of this study was to identify currently predominant etiologies of ALF in a monocenter study at a leading transplant center in Germany.
Patients and Methods: The data of 161 patients admitted with ALF from 1/2002 to 12/2012 were analyzed retrospectively. All patients fulfilled the criteria of the, Acute Liver Failure Study Group Germany" (international normalized ratio (INR) >= 1.5, hepatic encephalopathy >= stage 1).
Results: DILI was the leading cause of ALF in this cohort. About 20 % of ALF patients with DILI died or received liver transplantats. Mortality rate was highest in ALF patients with unknown etiology and those without specific therapy available.
Conclusions: In Europe ALF etiologies exhibit a North-South divide. In Germany the most common cause for ALF is idiosyncratic pharmacological intoxication followed by acute hepatitis B.

• 出版日期2014-5