A novel fluorescent enantioselective discrimination of lansoprazole based on a chiral N,N '-dioxide-Sc(III) complex

作者：Li, Miaosi; Fu, Yingzi^*; Cui, Xin; Chen, Min; Liu, Xiaohua; Lin, Lili; Feng, Xiaoming

来源：Tetrahedron Letters, 2010, 51(27): 3511-3513.

DOI：10.1016/j.tetlet.2010.04.094

• AMINO-ACIDS
• CYCLODEXTRIN
• RECOGNITION

A good chiral discrimination of lansoprazole (LAN) enantiomers was realized by a chiral N,N'-dioxideSc(III) complex, which was based on a fluorescent method through an 'off-on' process. The chiral ligand, N,N'-dioxide, coordinated with scandium(III) triflate forming an organic-metal complex as a chiral selector. Then the LAN enantiomers reacted with the selector and generated different signals in fluorescence. A distinct enantiomeric difference was observed with good repeatability, low detection limit, good linear range, and highly enantiomeric selectivity. At last, this study had offered a quantitative measurement of the enantiomer composition.

• 出版日期2010-7-7
• 单位四川大学; 西南大学