Antidiarrheal and Bronchodilatory Activities of Olive Extract

作者：Khan Arif Ullah; Gilani Anwarul Hassan^*

来源：Latin American Journal of Pharmacy, 2011, 30(1): 5-9.

• Antidiarrheal
• Bronchodilatory
• Olea europea
• olive

This study describes the antidiarrheal and airways-relaxant effects of the olive or Olea europea crude extract (Oe.Cr). Oe.Cr which tested positive for the presence of flavonoids and saponins, inhibited the castor oil-induced diarrhea in mice at the dose range of 100-300 mg/kg. When tested against carbachol (CCh)-mediated bronchoconstriction in rats under anesthesia, Oe.Cr dose-dependently (30-300 mg/kg) suppressed the CCh (1 mu mol/kg)-induced increase in the inspiratory pressure. In isolated guineapig trachea, Oe.Cr caused relaxation of both CCh (1 mu M) and high K(+) (80 mM)-induced contractions, like that caused by verapamil, suggestive of Ca(++) channel blockade. These results indicate that olive exhibit antidiarrheal, bronchodilatory and tracheo-relaxant activities.

• 出版日期2011-2