Women's interest in taking tamoxifen and raloxifene for breast cancer prevention: response to a tailored decision aid

作者：Fagerlin Angela^*; Dillard Amanda J; Smith Dylan M; Zikmund Fisher Brian J; Pitsch Rosemarie; McClure Jennifer B; Greene Sarah; Alford Sharon Hensley; Nair Vijayan; Hayes Daniel F; Wiese Cheryl; Ubel Peter A

来源：Breast Cancer Research and Treatment, 2011, 127(3): 681-688.

DOI：10.1007/s10549-011-1450-1

• Decision aids
• Patient education
• Tamoxifen
• Raloxifene
• Breast cancer prevention

Although tamoxifen can prevent primary breast cancer, few women use it as a preventive measure. A second option, raloxifene, has recently been approved. The objective of the study was to determine women's interest in tamoxifen and raloxifene after reading a decision aid (DA) describing the risks and benefits of each medication. Women with 5-year risk of breast cancer a parts per thousand yen 1.66 from two large health maintenance organizations were randomized to receive a DA versus usual care. After reading an on-line DA that discussed the risks and benefits of tamoxifen and raloxifene, women completed measures of risk perception, decisional conflict, behavioral intentions, and actual behavior related to tamoxifen and raloxifene. 3 months following the intervention, 8.1% of participants had looked for additional information about breast cancer prevention drugs, and 1.8% had talked to their doctor about tamoxifen and/or raloxifene. The majority, 54.7%, had decided to not take either drug, 0.5% had started raloxifene, and none had started tamoxifen. Participants were not particularly worried about taking tamoxifen or raloxifene and did not perceive significant benefits from taking these drugs. Over 50% did not perceive a change in their risk of getting breast cancer if they took tamoxifen or raloxifene. After reading a DA about tamoxifen and raloxifene, few women were interested in taking either breast cancer prevention drug.

• 出版日期2011-6