Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration

作者：Herraiz Ignacio; Simon Elisa; Isabel Gomez Arriaga Paula; Manuel Martinez Moratalla Jose; Garcia Burguillo Antonio; Lopez Jimenez Elena Ana; Galindo Alberto^*

来源：International Journal of Molecular Sciences, 2015, 16(8): 19009-19026.

DOI：10.3390/ijms160819009

• placental insufficiency
• preeclampsia
• intrauterine growth restriction
• placental abruption
• angiogenesis
• sFlt-1
• PlGF

Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to any particular placental insufficiency-related disease, has marked an important step for improving their early diagnosis and prognosis assessment. However, sFlt-1/PlGF has not been yet established as a part of most guidelines. We will review the current evidence on the clinical utility of sFlt-1/PlGF and propose a new protocol for its clinical integration.

• 出版日期2015-8