Delayed Type Hypersensitivity in the Pathogenesis of Recurrent Herpes Stromal Keratitis

作者：Hawthorne Kristen M^*; Dana Reza; Chodosh James

来源：Seminars in Ophthalmology, 2011, 26(4-5): 246-250.

DOI：10.3109/08820538.2011.588659

• dendritic cell
• herpes simplex virus
• keratitis

Recurrent herpes stromal keratitis (HSK) is one of the leading causes of blindness in the developed world. Cyokines characteristic of Th1 cells (in particular IFN-gamma and IL-2) have been shown to dominate in HSK in addition to mechanisms by nonspecific, antigen-independent effector cells such as neutrophils, basophils, and monocytes. More recently, the migration and maturation of dendritic cells (DC) within the corneal stroma of patients with HSK have been recognized as contributors to recurrent disease, suggesting a role for delayed type hypersensitivity (DTH) in the immunopathogenesis of HSK. The role of DC and DTH in recurrent HSK has not been studied extensively and experimental models of recurrent HSK focusing on DTH as the pathogenesis and viral particles as the triggering antigen may contribute to better understanding of the disease.

• 出版日期2011-9