Atypical transforming growth factor-beta signaling in the hypothalamus is linked to diabetes

Araujo Eliana P<sup>*</sup>; de Souza Claudio T; Velloso Licio A

doi:10.1038/nm.3673

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Atypical transforming growth factor-beta signaling in the hypothalamus is linked to diabetes

作者：Araujo Eliana P^*; de Souza Claudio T; Velloso Licio A

来源：Nature Medicine, 2014, 20(9): 985-987.

DOI：10.1038/nm.3673

摘要

Aging and a high-fat diet are predisposing factors for type 2 diabetes. A study in mice suggests that dietary fat and aging lead to atypical transforming growth factor-beta 1 signaling in the hypothalamus, which disturbs whole-body glucose regulation.