Antiprotozoal, Antimycobacterial and Cytotoxic Potential of Twenty-Three British and Irish Red Algae

作者：Allmendinger Andrea; Spavieri Jasmine; Kaiser Marcel; Casey Rosalyn; Hingley Wilson Suzie; Lalvani Ajit; Guiry Michael; Blunden Gerald; Tasdemir Deniz^*

来源：Phytotherapy Research, 2010, 24(7): 1099-1103.

DOI：10.1002/ptr.3094

• Marine red algae
• Trypanosoma
• Leishmania
• Mycobacterium
• cytotoxicity

As part of our continuing research on seaweeds, we have screened the crude extracts of 23 red marine algae collected from England and Ireland. The clinically important blood-stage life forms of Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani and Mycobacterium tuberculosis were used as test organisms in the in vitro assays. The selectivity of the extracts was determined by using mammalian skeletal myoblast (16) cells. All algal extracts showed activity against T. brucei rhodesiense, with Corallina officinalis and Ceramium virgatum being the most potent (IC(50) values 4.8 and 5.4 mu g/ml), whilst none of the algal extracts inhibited the growth of T. cruzi. Except for Porphyra leucosticta, extracts from all seaweeds also showed leishmanicidal activity with IC(50) values ranging from 16.5 to 85.6 mu g/ml. Only the crude extract of Calliblepharis jubata showed some weak activity against Mycobacterium tuberculosis (MIC value 256 mu g/ml), while the others were inactive at this concentration. Corallina officinalis was the only seaweed that displayed some marginal cytotoxicity (IC(50) value 88.6 mu g/ml), and all remaining extracts were non-toxic towards 16 cells at 90 mu g/ml concentration. To our knowledge, this is the first study reporting antiprotozoal and antimycobacterial activity of British and Irish red algae.

• 出版日期2010-7