Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero) aryl-1H-indazoles from hydrazine, o-chloro (hetero) benzophenones, and (hetero) aryl bromides

作者：Wiethan Carson; Lavoie Christopher M; Borzenko Andrey; Clark Jillian S K; Bonacorso Helio G^*; Stradiotto Mark^*

来源：Organic and Biomolecular Chemistry, 2017, 12(23): 5062-5069.

DOI：10.1039/c7ob00841d

The nickel-catalyzed cyclization of in situ generated ortho-chlorobenzophenone hydrazone derivatives, to afford 3-(hetero) aryl-1H-indazoles, is documented for the first time. The product 1H-indazoles can be transformed subsequently in a one-pot procedure into 1,3-di(hetero) aryl-1H-indazoles via copper-catalyzed N-arylation with (hetero) aryl bromides.

• 出版日期2017-6-21