Adjuvant treatment in resected non-small cell lung cancer: Current and future issues

作者：Remon Jordi^*; Lianes Pilar; Martinez Susana; Velasco Montserrat; Querol Rosa; Zanui Montserrat

来源：Critical Reviews in Oncology/Hematology, 2013, 88(2): 375-386.

DOI：10.1016/j.critrevonc.2013.05.017

• Adjuvant chemotherapy
• Lung cancer
• Stage IB-IIIA

The cornerstone of treatment for early-stage non-small cell lung cancer (NSCLC) has been surgical resection. In the last five years two phase III trials have provided evidence of adjuvant platinum-based chemotherapy for completely resected stage II-IIIA patients. We review the evidence supporting adjuvant therapy in early-stage NSCLC; we discuss new issues surrounding adjuvant therapy such as treatment in the elderly-unfit population, treatment toxicity and its influence on outcomes, the importance of histology and gender in adjuvant treatment; and we discuss the future landscape of early-stage NSCLC research, namely, therapeutic strategies exploiting pharmacogenomic and gene-expression profiling, in an attempt to customize the treatment.

• 出版日期2013-11