Deltamethrin resistance in Aedes aegypti results in treatment failure in Merida, Mexico

作者：Vazquez Prokopec Gonzalo M; Medina Barreiro Anuar; Che Mendoza Azael; Dzul Manzanilla Felipe; Correa Morales Fabian; Guillermo May Guillermo; Bibiano Marin Wilbert; Uc Puc Valentin; Geded Moreno Eduardo; Vadillo Sanchez Jose; Palacio Vargas Jorge; Ritchie Scott A; Lenhart Audrey; Manrique Saide Pablo

来源：PLoS Neglected Tropical Diseases, 2017, 11(6): e0005656.

DOI：10.1371/journal.pntd.0005656

The operational impact of deltamethrin resistance on the efficacy of indoor insecticide applications to control Aedes aegypti was evaluated in Merida, Mexico. A randomized controlled trial quantified the efficacy of indoor residual spraying (IRS) against adult Ae. aegypti in houses treated with either deltamethrin (to which local Ae. aegypti expressed a high degree of resistance) or bendiocarb (to which local Ae. aegypti were fully susceptible) as compared to untreated control houses. All adult Ae. aegypti infestation indices during 3 months post-spraying were significantly lower in houses treated with bendiocarb compared to untreated houses (odds ratio <0.75; incidence rate ratio <0.65) whereas no statistically significant difference was detected between the untreated and the deltamethrin-treated houses. On average, bendiocarb spraying reduced Ae. aegypti abundance by 60% during a 3-month period. Results demonstrate that vector control efficacy can be significantly compromised when the insecticide resistance status of Ae. aegypti populations is not taken into consideration.

• 出版日期2017-6