Application of Chromatographic Data in QSAR Studies of 3-[omega-(4-Arylpiperazin-1-yl)alkyl]pyrimido[5,4-c]quinolin-4(3H)-one Derivatives as 5-HT1A Receptor Ligands

作者：Zydek Grazyna^*; Brzezinska Elzbieta; Stanczak Andrzej; Lewgowd Wieslawa

来源：Journal of Chromatographic Science, 2014, 52(7): 596-603.

DOI：10.1093/chromsci/bmt082

The activity of several 3-[omega-(4-arylpiperazin-1-yl) alkyl]pyrimido[5,4-c]quinolin-4(3H)-ones (LCAPs) with well-defined serotonin 1A (5-HT1A) receptor affinity was described by using chromatographic and calculated physicochemical parameters in quantitative structure-activity relationship analysis. Normal-phase thin-layer chromatography plates impregnated with solutions of L-aspartic acid, L-serine, L-phenylalanine, L-tryptophan, L-tyrosine, L-asparagine, L-threonine and their mixtures (denoted as S1-S11 biochromatographic models) were used with two mobile phases as a model of the interaction between LCAP and 5-HT1A receptors. Molecular descriptors for the investigated compounds were calculated by using HyperChem and ACD/Labs programs. The significant relationship explains that 82% of the variance was successfully validated by leave-one-out and leave-many-out tests. The results demonstrated that this model has significant predictive ability and can be used for the preliminary screening of newly synthesized potential 5-HT1A receptor ligands.

• 出版日期2014-8