An Efficient Total Synthesis of a Potent Anti-Inflammatory Agent, Benzocamphorin F, and Its Anti-Inflammatory Activity

作者:Liao Yu Ren; Kuo Ping Chung; Liang Jun Weil; Shen Yuh Chiang; Wu Tian Shung*
来源:International Journal of Molecular Sciences, 2012, 13(8): 10432-10440.
DOI:10.3390/ijms130810432

摘要

A naturally occurring enynyl-benzenoid, benzocamphorin F (1), from the edible fungus Taiwanofungus camphoratus (Antrodia camphorata) was characterized by comprehensive spectral analysis. It displays anti-inflammatory bioactivity and is valuable for further biological studies. The present study is the first total synthesis of benzocamphorin F and the developed strategy described is a more efficient procedure that allowe the large-scale production of benzocamphorin F for further research of the biological activity both in vitro and in vivo.