A virosomal vaccine against candidal vaginitis: Immunogenicity, efficacy and safety profile in animal models

作者：De Bernardis Flavia; Amacker Mario; Arancia Silvia; Sandini Silvia; Gremion Christel; Zurbriggen Rinaldo; Moser Christian; Cassone Antonio^*

来源：Vaccine, 2012, 30(30): 4490-4498.

DOI：10.1016/j.vaccine.2012.04.069

• Candida albicans
• Aspartyl proteinase 2
• Virosomes
• Vaccine
• Recurrent vulvo-vaginal candidiasis

A novel vaccine (PEV7) consisting of a truncated, recombinant aspartyl proteinase-2 of Candida albicans incorporated into influenza virosomes was studied. This vaccine candidate generated a potent serum antibody response in mouse and rat following intramuscular immunization. Anti-Sap2 IgG and IgA were also detected in the vaginal fluid of rats following intravaginal or intramuscular plus intravaginal administration. In a rat model of candidal vaginitis, PEV7 induced significant, long-lasting, likely antibody-mediated, protection following intravaginal route of immunization. PEV7 was also found to be safe in a repeated-dose toxicological study in rats. Overall, these data provide a sound basis to envisage the clinical development of this new candidate vaccine against candidal vaginitis.

• 出版日期2012-6-22