Discovery of a multi-bond forming, four-step tandem process: construction of drug-like polycyclic scaffolds

作者:Grafton Mark W; Farrugia Louis J; Senn Hans Martin; Sutherland Andrew*
来源:Chemical communications, 2012, 48(64): 7994-7996.
DOI:10.1039/c2cc33649a

摘要

A one-pot tandem process involving an Overman rearrangement, ring closing enyne metathesis and a hydrogen bonding directed Diels-Alder reaction has been developed for the efficient diastereoselective synthesis of functionalised amino substituted tetralin and indene ring systems.

  • 出版日期2012